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September 30, 2025

10 Topics To Talk About In A Podcast for B2B Growth in 2025

By
Fame Team

Choosing the right topic for your B2B podcast is the foundation of its success. It's not just about filling airtime; it's about carving out a niche, building authority, and creating a show that resonates with your ideal customer profile. A generic approach leads to a forgettable podcast, failing to capture the attention of busy executives or specialized professionals. The key is to find topics to talk about in a podcast that align with your brand's expertise while solving your audience's most pressing problems.

This list isn't just a collection of ideas; it's a strategic guide to selecting concepts that will attract high-value listeners, foster engagement, and ultimately drive business growth. We'll explore ten powerful themes, moving beyond the obvious to give you actionable insights for launching a podcast that stands out. To truly stand out in the crowded B2B podcast landscape, consider how a strong understanding of brand positioning strategies can inform and shape your podcast's unique voice.

From there, we will explore why investing in strategic B2B podcast promotion is crucial for maximizing visibility and achieving measurable audience growth. Consider this your roadmap to creating not just a podcast, but a core asset for your company's marketing and demand generation engine.

1. Niche Industry Deep Dives & Trend Analysis

Broad business advice is everywhere. To truly stand out and attract a dedicated B2B audience, you must become the definitive authority in a specific vertical. This is where niche deep dives excel, offering hyper-relevant insights that generalist shows simply cannot match. By focusing intensely on a single industry’s challenges, emerging technologies, and future trajectory, you create content that is indispensable to its key players. This is one of the most effective topics to talk about in a podcast for building unmatched brand authority.

This approach transforms your podcast from a general marketing asset into an essential educational resource for your ideal customer persona. For instance, the popular podcast Acquired dissects tech company acquisitions and IPOs, establishing hosts Ben Gilbert and David Rosenthal as experts in that domain. Similarly, Fintech Insider concentrates exclusively on financial technology, becoming a go-to source for industry professionals.

How to Implement This Topic

  • Define Your Listener Persona: Go beyond basic demographics. Pinpoint the specific job titles, daily challenges, and strategic goals of your target listener within the niche.
  • Leverage Internal Experts: Your company's subject matter experts are your greatest asset. Feature engineers, product managers, and strategists who live and breathe the industry's complexities.
  • Use Proprietary Data: Release exclusive insights from your company’s research or data analysis. This creates unique, defensible content that competitors cannot replicate.
  • Partner Strategically: Collaborate with industry associations or complementary technology partners like Chili Piper, which specializes in inbound conversion for B2B revenue teams, to co-create content and cross-promote to a built-in, relevant audience.

2. Business and Entrepreneurship

Diving into the world of business and entrepreneurship offers a vast landscape of compelling topics for a podcast. This category focuses on the stories behind successful ventures, leadership philosophies, marketing tactics, and professional growth. By featuring interviews with industry titans, dissecting pivotal business case studies, and offering actionable advice, you can create a show that inspires and educates ambitious professionals. This approach turns your podcast into a valuable resource for anyone looking to build or scale a business.

Business and Entrepreneurship

Shows like How I Built This with Guy Raz masterfully uncover the origin stories of well-known companies, while The Tim Ferriss Show deconstructs the habits and tactics of world-class performers. These podcasts succeed by providing tangible takeaways that listeners can apply to their own careers and ventures. The key is to transform broad business concepts into specific, engaging narratives that resonate with your target audience. Discover more by reading our guide on starting a business podcast.

How to Implement This Topic

  • Focus on a Specific Niche: Instead of "business," narrow your focus to "SaaS leadership," "e-commerce growth hacks," or "B2B marketing for startups." A defined niche attracts a more dedicated and engaged audience.
  • Share Authentic Experiences: Don’t just interview others. Authentically share your own business wins, failures, and lessons learned. This vulnerability builds trust and a stronger connection with your listeners.
  • Provide Actionable Takeaways: End every episode with clear, concise action items. Listeners should walk away with a specific strategy or tool they can implement immediately.
  • Prepare Thoroughly for Guests: Research your guests extensively to ask insightful questions that go beyond their standard talking points. The goal is to uncover fresh stories and unique perspectives.

3. Health and Wellness

Health and wellness podcasts have carved out a significant niche, addressing topics from fitness and nutrition to mental health and biohacking. These shows build highly engaged communities by offering actionable advice that listeners can apply to improve their daily lives. By featuring medical professionals, researchers, and wellness experts, you can provide evidence-based insights and personal stories of transformation, establishing a deep sense of trust and authority with your audience.

This topic is powerful because it taps into the universal human desire for self-improvement and well-being. Podcasts like The Model Health Show and The Doctor's Farmacy with Dr. Mark Hyman have built massive followings by translating complex health information into accessible lifestyle changes. This positions the podcast not just as entertainment, but as an essential tool for personal growth, making it one of the most resonant topics to talk about in a podcast.

Health and Wellness

How to Implement This Topic

  • Prioritize Credibility: Always include proper medical disclaimers and encourage listeners to consult their healthcare providers. Thoroughly vet the credentials and expertise of every guest to maintain trust and integrity.
  • Focus on Lifestyle Application: Frame discussions around practical, sustainable lifestyle adjustments rather than prescriptive medical advice. This makes the content safer and more universally applicable.
  • Cite Scientific Evidence: Back up claims with references to peer-reviewed scientific studies and credible research. This adds weight to your content and distinguishes your podcast from less rigorous sources.
  • Create a Supportive Community: Use your platform to foster a positive community around shared health goals. You can extend this engagement through dedicated channels managed by a specialized B2B social media agency to ensure consistent, high-quality interaction.

4. Technology and Innovation

Podcasts dedicated to technology and innovation serve as a crucial pulse-check for professionals navigating the digital frontier. These shows explore emerging trends, from artificial intelligence and blockchain to cybersecurity and digital transformation. By featuring tech leaders, dissecting startup innovations, and explaining complex concepts in accessible terms, you can build a highly engaged audience eager to stay ahead of the curve. Choosing this as one of the topics to talk about in a podcast positions your brand at the forefront of the industry’s evolution.

This topic allows you to attract a broad yet specific audience, from venture capitalists and founders to enterprise tech buyers and developers. Shows like Darknet Diaries have captivated listeners with deep dives into hacking stories, while The Vergecast has become a staple for consumer tech news. These examples demonstrate the power of specializing within the vast technology landscape to create an indispensable resource.

Technology and Innovation

How to Implement This Topic

  • Explain Complex Concepts Simply: Break down intricate topics like machine learning or quantum computing into digestible, practical explanations for a business audience.
  • Feature Diverse Innovators: Go beyond household names. Interview emerging founders, engineers, and thinkers who offer fresh, ground-level perspectives on technological shifts.
  • Stay Radically Current: Technology moves quickly. Dedicate resources to trend-spotting and be prepared to produce timely episodes that react to major industry news and product launches.
  • Develop a Niche Expertise: Instead of covering all of tech, focus on a specific vertical like MarTech, cybersecurity, or FinTech to build deeper authority and attract a more dedicated listenership. An effective podcast marketing strategy for technology podcasts will help you identify and reach this specific audience.

5. Personal Development and Self-Improvement

In a demanding B2B environment, professional growth is inextricably linked to personal development. Podcasts focusing on mindset, productivity, and leadership skills resonate deeply with ambitious professionals seeking a competitive edge. This format moves beyond tactical business advice to explore the foundational habits and mental models that drive sustained success. It is one of the most impactful topics to talk about in a podcast for building a loyal, engaged community around shared growth values.

This approach positions your brand as a holistic partner invested in your audience's complete success, not just their professional transactions. Shows like The Brendon Show and The Life Coach School Podcast have built massive followings by providing actionable strategies for high performance and mindset transformation. By offering tangible advice for personal improvement, you create a powerful, enduring connection with your listeners.

How to Implement This Topic

  • Focus on a Core Transformation: Center your show on a specific area of development, such as leadership communication, overcoming imposter syndrome, or mastering productivity, to attract a dedicated audience.
  • Share Authentic Stories: Go beyond theory by sharing genuine personal experiences, including failures and lessons learned. Vulnerability builds trust and makes the content more relatable and impactful.
  • Provide Actionable Steps: Each episode should conclude with specific, easy-to-implement steps or challenges that listeners can apply immediately to see tangible results in their lives.
  • Feature Listener Journeys: Showcase success stories from your audience to provide social proof and inspiration. This fosters a strong sense of community and demonstrates the real-world value of your content. To ensure these interviews are effective, it's wise to review some best practices on how to prepare guests for an interview.

6. Pop Culture and Entertainment

While seemingly tailored for B2C, pop culture offers a surprisingly potent angle for B2B podcasts. Tying industry topics to current movies, TV shows, or viral trends creates a relatable and highly engaging entry point for complex subjects. This approach humanizes your brand, captures attention in a crowded market, and makes abstract business concepts more memorable and shareable. It’s one of the more creative topics to talk about in a podcast that can differentiate your brand significantly.

This strategy helps build a strong community by tapping into shared cultural experiences. For instance, NPR’s Pop Culture Happy Hour has mastered the art of witty, insightful analysis, building a loyal following. Similarly, the hosts of Office Ladies use a beloved TV show as a vehicle for storytelling, creating an intimate connection with listeners. A B2B brand can adapt this by discussing the business strategies seen in Succession or the leadership lessons from a blockbuster film, linking entertainment to professional development.

How to Implement This Topic

  • Find a B2B Crossover: Identify cultural phenomena that have a clear, logical connection to your industry. This could be analyzing the supply chain logistics in a sci-fi movie or the marketing campaign of a new album.
  • Stay Relevant and Timely: Capitalize on trending topics. Your commentary is most valuable when the subject is at the peak of public conversation.
  • Create Recurring Segments: Develop consistent formats, like a "Weekly Binge" or "Trend Spotlight," that listeners can look forward to. This builds anticipation and habit.
  • Engage Fan Communities: Use social media to discuss episodes and theories with relevant fan groups, tapping into existing conversations. Promoting these clips through a B2B social media agency can amplify your reach to both niche and broad audiences.

7. History and Storytelling

While seemingly unconventional for a B2B context, weaving historical narratives into your podcast can be a powerfully distinctive strategy. By examining the history of an industry, the evolution of a core technology, or the backstory of a pivotal business failure, you provide deep context that informs current and future strategies. This approach positions your brand as a source of wisdom and perspective, not just tactical advice. It's one of the most creative topics to talk about in a podcast to build a memorable and sophisticated brand identity.

This method transforms your content from a simple business discussion into a compelling narrative that resonates on a human level. For instance, Dan Carlin’s Hardcore History and Mike Duncan’s The History of Rome have built massive followings by making complex historical events accessible and engaging. A B2B brand can adapt this by creating a show like "The History of SaaS" or "Revolutions in Manufacturing," using storytelling to explain how past innovations and market shifts shape today's business landscape.

How to Implement This Topic

  • Connect Past to Present: Don't just recount history. Explicitly draw parallels between historical events and modern business challenges, offering listeners timeless lessons.
  • Focus on Compelling Characters: Every great story has memorable figures. Profile the innovators, disruptors, and even the cautionary tales from your industry's history.
  • Maintain Factual Accuracy: Rigorously research your topics using primary sources and expert interviews to build credibility. Inaccuracy can quickly damage your authority.
  • Leverage Narrative Arcs: Structure episodes with a clear beginning, middle, and end. Use narrative tension and resolution to keep your audience hooked from start to finish.

8. Interview and Conversation Shows

Leveraging the expertise and stories of others is a powerful way to create compelling content. Interview shows feature in-depth conversations with industry leaders, subject matter experts, and influential figures, transforming your podcast into a hub for diverse perspectives. This format allows you to borrow authority from your guests while providing immense value to your audience, making it one of the most effective topics to talk about in a podcast for building a network and generating fresh insights.

This approach positions your brand as a central connector and thought leader within your industry. Instead of relying solely on internal knowledge, you curate conversations that address your audience's most pressing questions. For example, The Tim Ferriss Show deconstructs the habits of world-class performers, while Armchair Expert with Dax Shepard explores the "messiness of being human" with celebrity guests. Both have built massive followings by mastering the art of the interview to uncover unique, actionable wisdom.

How to Implement This Topic

  • Define Your Guest Persona: Identify the specific roles, expertise, and perspectives that will most resonate with your target listeners. Aim for guests who can speak directly to your audience's pain points.
  • Develop a Signature Style: Differentiate your show by creating a unique interview approach. Whether it's rapid-fire questions, deep storytelling, or a tactical focus, a consistent style builds a loyal following.
  • Conduct Thorough Research: Go beyond a guest's LinkedIn profile. Listen to their other interviews, read their work, and prepare unique questions that allow them to share new stories and insights. This preparation is key to a memorable conversation. For a detailed guide on this, explore these proven techniques for how to conduct a podcast interview.
  • Focus on Authentic Dialogue: Create a comfortable, conversational environment rather than a rigid Q&A session. The best interviews feel like an authentic, engaging discussion that the listener gets to witness firsthand.

9. Comedy and Humor

While it may seem counterintuitive for a B2B audience, integrating comedy and humor can dramatically increase listener engagement and make your brand more memorable. This approach moves beyond dry corporate messaging, using wit to entertain, build rapport, and humanize your company. When executed well, it creates a powerful emotional connection with your audience, making them more receptive to your core message and fostering a loyal community around your brand.

This strategy is about more than just telling jokes; it’s about establishing a unique and relatable brand voice. Shows like Conan O'Brien Needs a Friend demonstrate how humor can disarm even the most high-profile guests, leading to more authentic conversations. Similarly, My Dad Wrote A Porno built a massive following by turning cringe-worthy source material into a shared comedic experience. These examples prove that humor is a versatile tool for creating standout content, which is why it's one of the most engaging topics to talk about in a podcast.

How to Implement This Topic

  • Develop a Consistent Comedic Voice: Define your brand’s style of humor. Is it satirical, observational, self-deprecating, or witty? This voice should align with your overall brand identity and resonate with your listener persona.
  • Create Recurring Segments or Bits: Establish inside jokes and recurring segments that your audience can look forward to. This builds a sense of community and makes listeners feel like part of an exclusive club.
  • Balance Humor with Value: Ensure that humor serves a purpose, whether it's to make a complex topic more digestible or to build a stronger connection with a guest. The comedy should enhance the content, not detract from its core value.
  • Test and Refine Your Material: If you’re incorporating scripted comedy, test your jokes on a small, trusted audience first. Use feedback to refine your timing and delivery, ensuring the humor lands effectively with your target listeners.

10. Educational and Learning

Positioning your B2B podcast as a primary educational resource can rapidly establish your brand as a foundational authority in its space. Unlike formats that focus on news or interviews, an educational podcast directly addresses the knowledge gaps of your target audience, teaching them specific skills or complex concepts in an accessible audio format. This approach transforms your show from a marketing channel into an indispensable professional development tool, creating a deeply loyal subscriber base.

This strategy is highly effective because it delivers tangible value, helping listeners solve real-world problems and advance their careers. Shows like 99% Invisible masterfully educate listeners on design and architecture through compelling storytelling, while Planet Money makes complex economic principles understandable and engaging. For a B2B audience, this means breaking down intricate software functionalities, explaining new regulatory landscapes, or teaching advanced strategic frameworks. These are some of the most impactful topics to talk about in a podcast for building trust.

How to Implement This Topic

  • Structure Content into a Curriculum: Organize your episodes into logical modules or seasons that build upon each other. This encourages listeners to start from the beginning and follow the entire series.
  • Use Storytelling and Analogies: Make dense or technical information digestible by weaving it into relatable narratives and analogies. Abstract concepts become memorable when tied to a compelling story.
  • Create Supplementary Resources: Enhance the learning experience by providing downloadable worksheets, checklists, or templates that correspond with episode content. This adds practical, hands-on value.
  • Feature Guest Instructors: Bring in credible experts from different fields to teach specific topics. This not only adds variety and authority but also helps cross-promote your podcast to their established audiences. If you want to explore more educational and learning topics, you can learn more about podcast topics on fame.so.

Top 10 Podcast Topic Comparison

Podcast GenreImplementation Complexity 🔄Resource Requirements ⚡Expected Outcomes 📊Ideal Use Cases 💡Key Advantages ⭐
True CrimeHigh (extensive research, fact-checking) 🔄🔄Significant (research, legal advice, interviews) ⚡⚡High engagement, loyal audience, social impact 📊📊Investigative storytelling, advocacy, niche audience 💡Large, dedicated audience; strong monetization ⭐⭐
Business and EntrepreneurshipModerate (expertise and guest coordination) 🔄Moderate (industry guests, research) ⚡Professional growth, networking, sponsorships 📊Business insights, leadership lessons, marketing 💡High-value sponsors; evergreen content ⭐⭐
Health and WellnessModerate to High (accuracy, disclaimers) 🔄🔄Moderate (medical experts, vetting) ⚡Positive impact, affiliate marketing, evergreen 📊Wellness advice, lifestyle optimization 💡Growing interest; impact potential ⭐⭐
Technology and InnovationHigh (technical knowledge, rapid updating) 🔄🔄High (equipment, software, research) ⚡⚡Influential, tech purchases, insider access 📊Emerging tech trends, product reviews 💡Tech-savvy audience; advertising opportunities ⭐⭐
Personal DevelopmentModerate (credibility, authentic content) 🔄Moderate (expertise, content preparation) ⚡Emotional connection, monetization (coaching) 📊Mindset, productivity, self-improvement 💡Universal appeal; meaningful impact ⭐⭐
Pop Culture and EntertainmentLow to Moderate (timeliness, trends) 🔄Moderate (up-to-date content, guest engagement) ⚡Broad appeal, social media engagement 📊Entertainment news, fandoms, cultural commentary 💡Accessible content; strong social interaction ⭐⭐
History and StorytellingHigh (deep research, accuracy) 🔄🔄Significant (source material, expert interviews) ⚡⚡Educational yet entertaining, engaged audience 📊Educational storytelling, historical insights 💡Evergreen content; academic support ⭐⭐
Interview and Conversation ShowsLow to Moderate (guest prep, interview skill) 🔄Moderate (guest booking, research) ⚡Network growth, authentic connections 📊Long-form interviews, diverse topics 💡Flexible format; guest audience crossover ⭐⭐
Comedy and HumorModerate (talent, content development) 🔄Moderate (hosting, production) ⚡Entertainment, loyal fanbase, viral potential 📊Stand-up, improv, satire, humorous commentary 💡Broad appeal; live show opportunities ⭐⭐
Educational and LearningHigh (curriculum design, teaching expertise) 🔄🔄Significant (educator guests, supplementary materials) ⚡⚡Lasting knowledge impact, partnerships 📊Skill-building, academic learning, lifelong education 💡Positive social impact; institutional ties ⭐⭐

From Topic Idea to Tangible ROI: The Power of Promotion

We've explored a comprehensive list of potential topics to talk about in a podcast, from deep dives into technological innovation to engaging interview series with industry leaders. However, selecting a compelling subject is merely the first step. A brilliant topic without a strategic promotional engine behind it is like a broadcast with no audience; the potential is there, but the impact remains unrealized. The true differentiator between a B2B podcast that simply exists and one that drives significant pipeline is a relentless focus on promotion.

The Real Value of Podcast Promotion

So, what are the benefits of investing in B2B podcast promotion? Investing in promotion transforms your podcast from a simple content piece into a powerful engine for business growth. It amplifies your reach, ensuring your valuable insights connect with your ideal customer profile (ICP). This process builds significant brand authority, establishes trust, and shortens the sales cycle by nurturing leads with high-value, educational content. Ultimately, strategic promotion delivers tangible ROI by converting listeners into qualified leads and loyal customers, directly contributing to your company's pipeline and revenue goals.

Actionable Next Steps: Turning Your Topic into a Tactic

Your journey doesn't end when you hit "stop recording." It's where the marketing begins. Effective B2B podcast promotion strategies involve a multi-channel approach to maximize reach and engagement.

  • Content Repurposing: Transform each episode into a suite of micro-assets. As our founder, Tom Hunt, often emphasizes, "A single podcast episode can fuel an entire month's worth of marketing content." Create audiograms for LinkedIn, quote graphics for social media, and short video clips of key moments. This extends the life of your content and meets your audience on their preferred platforms.
  • SEO and Discoverability: Develop detailed, SEO-optimized show notes for every episode. A full transcript not only makes your content more accessible but also provides a wealth of keywords for search engines to crawl, helping new listeners discover your show organically. To streamline this process, exploring various speech-to-text tools can significantly reduce manual effort and ensure accuracy.
  • Community Building: Leverage your owned channels. Use a dedicated email newsletter, managed by our B2B Email & Newsletter Agency, to announce new episodes and share behind-the-scenes content with your most engaged subscribers. This builds a loyal community that eagerly awaits each new release. Our B2B Social Media Agency can further amplify this by fostering conversations on platforms where your ideal customers are most active.

By implementing these tactics, your corporate podcast becomes more than just a series of conversations; it becomes a central pillar of your demand generation strategy. How can podcast marketing services boost our company's visibility? By systematically executing a multi-channel promotional playbook. Agencies like Fame offer comprehensive podcast marketing services for B2B startups and established companies alike. Typical packages include guest outreach, content repurposing for social media, SEO optimization for discoverability, and audience growth campaigns. This integrated approach ensures your corporate podcast doesn't just produce content but actively builds brand awareness, generates leads, and drives measurable business results, helping you achieve significant audience growth.


Ready to transform your podcast from a simple idea into a powerful revenue engine? Fame specializes in turning B2B podcasts into strategic marketing assets that build authority and drive growth. Let us handle the production and promotion, so you can focus on sharing your expertise.

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